- 36 years and above patients are considered as advanced maternal age patients.
- One egg has 4.5% capacity to generate into an embryo. So collecting more eggs is the only way forward which may require more than 1 egg retrieval.
- As embryo biopsy is the prime requirement to find out healthy embryo, there is a need to freeze all the embryo at day 5.
- Even the embryo is genetically tested, it will never implant in 55-65% cases in normal uterine lining. So only PGT-A shall not suffice.
- Combination of PGT and ERA, which highlights the personalized implantation window period should be carried out in advanced maternal age cases.
- Therefore, Advanced Maternal age= Day 5 Embryo + PGT-A + Freeze all + ERA
Patients are confused about the time to start the IVF treatment. Should the age be considered as the parameter or the duration of the treatment? In Indian female, age beyond 35, IVF will be a better option. More than 5 years of infertility period again strongly indicates IVF treatment . At any point, if AMH is less than 2.0, IVF is strongly indicated. In the era of IVF treatments, 3 IUI attempts are enough. Due to lack of regulations, patients are confused where to start the IVF treatment. There are no set parameters to indicate which is the best centre for IVF treatments. But according to me, the following criteria is important in a IVF centre: • More than 5 years of specialty infertility experience of the doctor. • Most latest technology with 0.3 micron clean air modular lab. • In-house and more than 5 years experience of embryology team. • Atleast one triple gas bench incubator. • Day 5 embryo transfer & freeze more strategy for all. Advanced m
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